Results
| PMID | 16128129 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 61 |
| Population details | 30 patients with endometriosis, 31 without endometriosis |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Ceska Gynekol. 2005 Jul;70(4):286-90. Galo, S| Zubor, P| Szunyogh, N| Kajo, K| Machalekova, K| Biringer, K| Visnovsky, J Gynekologicko-porodnicka klinika JLF UK a MFN, Martin, Slovenska republika. silvestergalo@yahoo.com OBJECTIVE: To determine serum levels of TNF-alpha (tumor necrosis factor alpha) as a prediction of endometriosis. DESIGN: Prospective clinical case control study. SETTING: Department of Obstetrics and Gynaecology and Department of Pathology, Jessenius Faculty Hospital, Kollarova 2, Martin, Slovakia. METHODS: The serum TNF-alpha was determined in women who underwent laparoscopy or laparotomy due to pelvic pain, infertility, dysmenorea or pelvic tumor. Endometriosis was confirmed histologically and classified by rAFS. RESULTS: On the basis of entering criteria 65 women were enrolled in this study. In 61 cases serum level of TNF-alpha was evaluated. The average serum level of TNF-alpha in the endometriotic group was 73.847 pg/ml (n=30) and without endometriosis was 21.089 pg/ml (n=31). We have found a significant statistical difference between the above mentioned groups in the medium levels of TNF-alpha (p<0.0001). We did not find statistical significance between TNF-alpha levels and in the group of women with endometriosis in relation to the stage of the disease (I.-II., III.-IV., adenomyosis). At a cut-off level of TNF-alpha 30 pg/ml there was a 63.33% sensitivity, 77.42% specificity, a positive prediction value 73.07%, and 68.57% of negative predictive value. CONCLUSION: TNF-alpha serum levels are good diagnostic markers of endometriosis in the spectrum of noninvasive methods. Mesh Terms: Adult| Biomarkers/blood| Endometriosis/blood/*diagnosis| Female| Humans| Sensitivity and Specificity| Tumor Necrosis Factor-alpha/*analysis|DA 2005/11/04 09:00 |
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